"Daawoyinka aashitada nukliyeerka" waxay isticmaalaan "nucleic acid", kuwaas oo tixraacaya walxaha sida DNA iyo RNA ee xakameynaya macluumaadka hidda-socodka, sida daroogo.Kuwani waxay u oggolaanayaan bartilmaameedka unugyada sida mRNA iyo miRNA oo aan lagu bartilmaameedsan karin dawooyinka miisaanka molecular hooseeya ee dhaqameed iyo daawooyinka ka hortagga jirka, waxaana jira rajo weyn oo dawooyinkan ah dawooyinka jiilka soo socda.Cilmi baaris firfircoon ayaa si caalami ah loo sameeyaa iyadoo la filayo inay horseeddo abuurista dawooyin markii hore aan la xalin karin.
Dhanka kale, waxaa la tilmaamay in horumarinta daawooyinka nucleic acid ay leeyihiin arrimo ay ka gudbaan, oo ay ku jiraan "(i) xasiloonidarada molecules nucleic acid ee jirka," "(ii) walaac ku saabsan falcelinta daroogada xun," iyo "(iii) dhibaato nidaamka bixinta daroogada (DDS)."Sidoo kale, shirkadaha Japan waxay ka dambeeyaan horumarinta daawooyinka nucleic acid sababtoo ah monopolization ee shatiyada ugu sarreeya ee nucleic acid ee shirkadaha Yurub iyo Maraykanka, taasoo keentay faragelinta horumarinta Japan.
Astaamaha daawooyinka nucleic acid
"Daawoyinka aashitada nukliyeerka" waa tignoolajiyada daawaynta ee jiilka soo socda oo leh hannaan hawleed gebi ahaanba ka duwan kan dawooyinka dhaqameed.Waxa kale oo ay muujisaa awoodda in si fudud loogu soo saaro unugyo cabbir dhexdhexaad ah iyo suurtogalnimada in lagu muujiyo waxtarka iyo badbaadada ka sarreeya kuwa dawooyinka lidka ku ah jidhka.Astaamahaas dartood, waxaa la filayaa in dawooyinka nucleic acid lagu isticmaalo kansarka iyo cudurrada la iska dhaxlo oo markii hore ay adkeyd in la daweeyo, iyo sidoo kale cudurrada ay ka mid yihiin hargabka iyo caabuqyada fayraska.
Noocyada daawooyinka nucleic acid
Dawooyinka Nucleic acid ee adeegsada DNA-da iyo RNA waxa ka mid ah kuwa bartilmaameedsada asiidhyada nuclei-ka marxaladda ay borotiinku ka samaysan yihiin DNA-ga genome (sida mRNA iyo miRNA) iyo kuwa bartilmaameedsada borotiinka.
Noocyada iyo sifooyinka daawooyinka nucleic acid (daawooyinka ka hortagga iyo daaweynta)
Waxaa jira dawooyin nucleic acid ah oo leh noocyo iyo astaamo kala duwan iyadoo loo eegayo bartilmaameedyada iyo hababka ficilka.
| Nooca | Bartilmaameedka | Goobta ficilka | Habka wax-qabadka | Soo koobid |
| siRNA | mRNA | Gudaha unugga (cytoplasm) | kala-baxa mRNA | RNA laba-geesood leh oo leh kala-goyn mRNA ah oo isku mid ahisku xigxiga (siRNA), timaha timaha hal xadhig leh ee RNA (shRNA), iwm.iyadoo la raacayo mabda'a RNAi |
| miRNA | microRNA | Gudaha unugga (cytoplasm) | beddelka microRNA | RNA labajibaaran, miRNA ee timaha biinanka hal xadhig lehama shaydaanka waxa loo isticmaalaa in lagu xoojiyo shaqada miRNA xumaatayby cillado |
| Dareen-xumo | mRNA miRNA | Gudaha unugga (Nucleus-ka, cytoplasm) | hoos u dhaca mRNA iyo miRNA, xannibaad kala goynta | RNA/DNA hal-xadhig leh oo ku xidhan mRNA bartilmaameedkaiyo miRNA si ay u keento hoos u dhac ama xannibaad,ama u dhaqmo si uu uga boodo exon marka la kala qaybinayo |
| Abtamer | Protein (protein ka baxsan unugyada) | Ka baxsan unugga | Joojinta shaqaynaysa | RNA/DNA hal-xadhig leh oo ku xidhan borotiinka la beegsanayosi la mid ah unugyada difaaca jirka/DNA |
| Qurxinta | Protein (cunsurka qoraalka) | Gudaha unugga (Nucleuska) | Joojinta qoraalka | DNA-da laba-jibbaaran oo leh isku xigxiga goobta xidhitaankaee qodobka qoraalka, kaas oo ku xidhan qodobka qoraalkaee hiddo-wadaha saameeyay si loo xakameeyo hidda-wadaha bartilmaameedka ah |
| Ribozyme | RNA | Gudaha unugga (cytoplasm) | RNA kala-baxa | RNA hal-xadhig leh oo leh shaqada enzyme ee isku xidhka iyo kala-goyntaee bartilmaameedka RNA |
| CpG oligo | Protein (receptor) | Oogada unugga | Immunopotentiation | Oligodeoxynucleotide oo leh CpG motif (DNA-kali-xaran) |
| Mid kale | - | - | - | Dawada Nucleic acids aan ahayn kuwa kor ku xusan kuwaas oo ku dhaqmafirfircooni difaaca jirka, sida PolyI: PolyC (RNA laba-xaran leh)iyo antigen |
Waqtiga boostada: Jul-25-2023
