Asalkii hore
Sanadihii la soo dhaafay, xuubka unugyada ka baxsan (EVs) ayaa soo jiitay dareenka dadka sidii qalab daweyn oo suurtagal ah;si kastaba ha ahaatee, saameynta daaweynta ee EVs ee endometriosis lama soo sheegin.Endometriosis waa cudur aan caadi ahayn oo ku dhaca haweenka oo aan caadi ahayn oo ku dhaca 10-15% haweenka da'da dhalmada, taasoo keenta calaamado kala duwan, taasoo keenta hoos u dhac ku yimaada tayada nolosha iyo culeys weyn oo bulsho.
Hordhaca Maqaalka
Bishii Luulyo 20, 2021, kooxda cilmi-baarista ee Professor Wang Guoyun oo ka socda Isbitaalka Qilu ee Jaamacadda Shandong ayaa daabacay warqad cilmi-baaris ah oo cinwaankeedu yahay "M1 Macrophage-Derived Nanovesicles Repolarize M2 Macrophages for Repolarize Development of Endometriosis" ee xuduudaha ee immunology, kaas oo ka hadlay soo saarista macrophages M1.Suurtagalnimada nanovesicles (NVs) ee daaweynta endometriosis.
Maqaalkani wuxuu isticmaalaa habka extrusion joogto ah si uu u diyaariyo M1NVs, oo isticmaalaa habka co-dhaqameed si ay u bartaan isbeddelada angiogenesis, socdaalka, duulaanka iyo tilmaamayaasha kale ee eutopic endometrial stromal unugyo (EM-ESCs) bukaanka qaba endometriosis.Isla mar ahaantaana, qaabka jiirka ee endometriosis ayaa la sameeyay, waxaana jiirarka lagu daaweeyay PBS, MONVs ama M1NVs, siday u kala horreeyaan, si loo qiimeeyo waxtarka iyo badbaadada M1NV ee daaweynta endometriosis.
Natiijooyinku waxay muujiyeen in M1NV-yada in vitro ay si toos ah ama si dadban u joojin karaan socdaalka iyo duulaanka EM-ESCs, oo ay joojiyaan angiogenesis.Qaabka mouse-ka, M1NVs waxay hakiyaan dhacdada endometriosis iyada oo loo marayo barnaamijka M2 macrophage iyada oo aan waxyeello u geysan xubnaha.Waxay muujinaysaa in M1NVs ay si toos ah u joojin karaan dhacdooyinka endometriosis, iyo sidoo kale waxaa lagu joojin karaa iyada oo lagu beddelayo nooca M2 macrophages oo loo beddelo nooca M1.Sidaa darteed, isticmaalka M1NVs waxay noqon kartaa hab cusub oo loogu talagalay daaweynta endometriosis.
Caawinta Foregene
Daraasadda, sababtoo ah M1NV waxaa loo diyaariyey iyadoo si joogto ah loo tuujiyo macrophages M1, maqaalku wuxuu isticmaalay qRT-PCR si loo ogaado qodobbada pro-bararka iyo calaamadaha M1 macrophage iNOS, TNF-a iyo IL-6 mRNA ee M1NV iyo M1 macrophages.Isku dhufashada is-beddelka.Natiijooyinku waxay muujiyeen in M1NVs ay ka kooban yihiin arrimo pro-bararka mRNA iyo M1 macrophage calamadaha, taas oo muujinaysa in M1NVs ay si wax ku ool ah u hayn karaan sifooyinka shaqada ee unugyada M1.Habkan cilmi-baarista ah wuxuu isticmaalaa QuickEasy Cell Direct RT-qPCR Kit-SYBR Cagaaran I ee Foregene
Qalabka Tooska ah ee Unugyada RT-qPCRfaahfaahin

Xaaladaha codsiga:
 
1. Nidaaminta hidda-socodka iyo falanqaynta muujinta, xaqiijinta xad-dhaafka hidde-sidaha ama saameynta faragelinta, baarista daroogada, iwm.;
2. Ogaanshaha muujinta hidda-wadaha ee unugyada ay adag tahay in la beero sida unugyada aasaasiga ah, unugyada asliga ah, iyo unugyada dareemayaasha;
3. Ogaanshaha mRNA ee shaybaarada sida exosomes iyo nanovesicles.
Astaamaha: