Marka loo eego tirakoobka Zhiliwo Big Data Platform, celceliska saamiga saamaynta ee tixraaca waraaqaha Foregene SCI ee Febraayo 2022 waa mid aad u sarreeya ilaa 5.8, iyo saameynta ugu sarreysa waa 8.947.
Iyada oo la adeegsanayo falanqaynta tirakoobka ee tirada waraaqaha SCI ee alaabada Foregene sannadihii la soo dhaafay, waxaa la ogaaday in isbeddelka kobaca uu yahay mid cad.
Foregene Co., Ltd. waxaa la aasaasay 2011. Waa shirkad bayoolaji ah oo isku dhafan R&D, wax soo saarka, iibinta iyo adeegga macaamiisha.Tan iyo markii la aasaasay, waxa ay diiradda saaraysay horumarinta molecular iyo bayoolajiga unugyada la xidhiidha teknoolajiyada, alaabta iyo adeegyada, iyo bixinta sifaynta nucleic acid, ogaanshaha nucleic acid iyo xal kale in inta badan isticmaalayaasha.Khadkeeda cilmi-baarista sayniska waxaa ka mid ah taxanaha sifaynta RNA, taxanaha sifaynta DNA, taxane RT/RT-PCR, taxane PCR toos ah, taxane PCR Mix, taxane toos ah RT-qPCR iyo "Sui" oo ah qalabyada la xidhiidha molecular.Alaabooyinka ayaa si weyn loogu isticmaalay cilmi-baarista aasaasiga ah ee dhinacyada cilmiga nolosha, daawada, beeraha, dawooyinka, iyo deegaanka.Macaamiisha waxay ku yaalaan jaamacadaha, machadyada cilmi-baarista, isbitaallada iyo qaybaha kale.
ZhiLiaowo waxay dooratay 6 dukumeenti dhibcaha sare leh ee Foregene bishii Febraayo tixraaca cilmi-baarayaasha, si loo yeesho faham qoto dheer iyo aqoon u leh alaabta Foregene.
Cinwaanka maqaalka: Adkeysiga substrate wuxuu nidaamiyaa kala soocida unugyada tarma ee pluripotent ee la kiciyay ee unugyada endothelial wadnaha
DOI: 10.1016/j.actbio.2022.02.032
Wakhtiga la sii daayo: 2022-2-27
Foregene
Alaabooyinka La Xusay Suugaanta
Ciwaanka Maqaalka: Aqoonsiga Saxeexa Mitochondrial Proteome Ee La Xidhiidha Xanuunka Dhiig-karka Sambabada ee Qaabka Jiirka
DOI: 10.1155/2022/8401924
Wakhtiga la sii daayo: 2022-2-21
Xiriirinta Qoraaga: Waaxda Farmashiyaha, Cusbitaalka Ugu Horeeya ee Jaamacadda Caafimaadka Xinjiang.
Abstract: Dhiig-karka halbowlaha sambabada (PAH) waa cudur halis ah oo horumarsan oo saameeya wadnaha iyo sambabada waana dhibaato caafimaad caalami ah oo saamaysa shakhsiyaadka iyo bulshada.Daraasaddan, qaabka jiirka ee PAH oo ay keentay monocrotaline (MCT) ayaa si guul leh loo dhisay.Borotiinnada mitochondrial ee koox kasta oo jiirka ah waxaa lagu go'aamiyay iyadoo la adeegsanayo farsamooyinka borotiinka ee aan summada lahayn.Iyada oo ku saleysan dhisidda iyo kobcinta shaqeynta ee shabakadaha isdhexgalka borotiinka-protein (PPI), 19-ka-horumarin hidde-sideyaasha mitochondrial iyo 123-hoos u-xakamaynta hiddo-wadaha mitochondrial ayaa lagu baaray jiirka PAH.Intaa waxaa dheer, tijaabinta xogta koox-kooxeed ee madaxbannaan, natiijadu waxay muujisay in 6 hiddo-wadaha mitochondrial ee kor loo habeeyay iyo 3 hiddo-wadaha mitochondrial-ka ee hoos loo dhigay ayaa si aad ah loogu muujiyay unugyada sambabada ee jiirka PAH.Hidde-sidayaasha dhexe ee mitochondrial-ka ee la beegsan karo ee suurtagalka ah ayaa lagu saadaaliyay heerka qoraalka iyadoo la adeegsanayo xogta RNAInter.Daraasadu waxay sidoo kale aqoonsatay bortezomib iyo carfilzomib inay yihiin dawooyinka suurtagalka ah ee daaweynta PAH.Ugu dambeyntii, daraasaddan ayaa iftiiminaysa iftiin cusub oo ku saabsan biomarkers muhiimka ah iyo xeeladaha daweynta ee PAHs.
Foregene
Alaabooyinka La Xusay Suugaanta
RT Easy II (Master Premix ee First Strand cDNA Synthesis ee qPCR)
Diiwaanka No.: RT-01021
Tilmaam: 50 × 10 μL rxns
Ciwaanka Maqaalka: Khasaaraha PTEN wuxuu siinayaa dareenka rapalogs ee kansarka unugyada kelyaha ee cad
DOI: 10.1038/s41401-022-00862-1
Wakhtiga la sii daayo: 2022-2-14
Xiriirinta Qoraaga: Waaxda Farmashiyaha, Isbitaalka Nanfang, Jaamacadda Caafimaadka Koonfurta, Guangzhou, Shiinaha
Soo koobid: Rapalog waa allostery mTORC1 inhibitor ah iyo daawo la ansixiyey oo loogu talagalay kansarka unugyada kelyaha ee cad cad (ccRCC).Daraasado la adeegsanayo khadadka unugyada ccRCC ee bukaan-socodka ee badan ayaa muujinaya in unugyada PTEN-ga yar ay muujiyaan dareen-celinta rapalogs.Khadadka unugyada CCRCC ee ku liidata PTEN, Rapalogs waxa ay joojiyeen kororka unugyada iyaga oo keenay in la xiro G0/G1 iyada oo aan la kicin apoptosis.Isticmaalka khadadka unugyada isogenic ee CRISPR/Cas9, daraasaddu waxay ansixisay xiriirka ka dhexeeya tirtirka PTEN iyo dareen-celinta Rapallo.Taas bedelkeeda, tirtirka VHL ama hiddo-wadaha chromatin-ka beddelka (PBRM1, SETD2, BAP1, ama KDM5C) ma aysan saameynin jawaabaha gacanta ee rapalogs.Muujinta ectopic ee mutant mTOR ee firfircoon (C1483F) ayaa la muujiyay si ay uga hortagto PTEN-ku-hortaagista koritaanka unugyada, halka soo-gelinta daawada u adkeysiga mTOR mutant (A2034V) ay u oggolaatay PTEN-deficient ccRCC unugyada si ay uga baxsadaan saameynta koritaanka-xakamaynta ee rapalogs.Unugyada CCRCC-da ee PTEN waxay aad ugu nugul yihiin saameynta xannibaadda ee temsirolimus ee socdaalka unugyada iyo korriinka burooyinka ee zebrafish iyo xenograft jiirarka.Daraasaduhu waxay muujiyeen in tirtirka PTEN uu la xiriiro dareenka rapallo waxaana loo isticmaali karaa calaamad ahaan xulashada daaweynta rapallo ee bukaanka ccRCC.
Foregene
Alaabooyinka La Xusay Suugaanta
Cinwaanka maqaalka: Habka firfircoon ee microbiota ee biyaha wasakhda ah ee cusbada leh ee leh khamiirka dulqaadka milixda iyo codsigeeda
DOI: 10.1016/j.jece.2022.107377
Wakhtiga la sii daayo: 2022-2-12
Unugga qoraaga: Dugsiga Sayniska Nolosha, Jaamacadda caadiga ah ee Jiangxi
Abstract: Biyaha wasakhda ah ee milixdu sareeyo waa biyaha wasakhda warshadaha oo leh qaybo isku dhafan, bayoloji-xumo iyo daaweyn bayoolaji oo adag.Si loo muujiyo habka gudaha ee bulshada microbial ee daaweynta biyaha wasakhda ah ee milixdu sareeyso ee khamiirka dulqaadka milixda, daraasadaha sifeynta ee bulshada microbial iyo arrimaha deegaanka ayaa la sameeyay.Heerarka ka saarista baahida ogsijiinta kiimikada, NH3-H iyo wadarta nitrogen ayaa si weyn loo hagaajiyay cabirka tijaabada ee WWTP.Natiijooyinka isku xigxiga ee sare-u-qaadka ah ayaa muujiyay in biofortification-ku si weyn u saameeyay qaab-dhismeedka bulshada microbial.Marka la eego heerka phylum, kooxaha Proteobacteria iyo Ascomycota ayaa u badan, halka heerka genus ay ku badan yihiin kooxaha Paracoccus iyo Meyeroi.Meyerella waxa ay door muhiim ah ka ciyaartaa daawaynta biyaha wasakhda ah ee milixdu sarayso, taas oo noqon karta sababta ugu wayn ee hufnaanta ka saarista wasakhaysan.Intaa waxaa dheer, pH, oksijiinta kala diri, iyo mugga saamaynta leh ayaa ahaa arrimo muhiim ah oo saameeya isku-xiga bulshooyinka microbial inta lagu jiro bioaugmentation, si kastaba ha ahaatee, tirada badan ee Meyerrotheca ma aysan saameynin uruurinta wasakhaysan ee saameynta leh.Daraasadani waxay si nidaamsan u daaha ka qaaday isbeddellada firfircoon iyo saadaasha shaqeynta ee noolaha inta lagu jiro bioaugmentation, iyo sidoo kale xiriirka ka dhexeeya bulshooyinka microbial iyo arrimaha deegaanka, oo dhigaya aasaas adag oo aragti ah oo loogu talagalay daaweynta dambe ee biyaha wasakhda ah ee-sare iyo cusbada.
Foregene
Alaabooyinka La Xusay Suugaanta
Ciwaanka Maqaalka: Falanqaynta Multi-Omics Kadib Maamulka Siilka ee Bacteroides jilicsan ee digaagga.
DOI: 10.3389/fmicb.2022.846011
Wakhtiga la sii daayo: 2022-2-16
Xiriirinta Qoraaga: Shaybaadhka Muhiimka ah ee Sichuan ee Horumarinta iyo Hal-abuurka Khayraadka Hiddaha ee Beeraha iyo Xoolaha
Abstract: Maabka taranka ee digaaggu waa xubin muhiim u ah samaynta ukunta.Xidhiidhka dhow ee ka dhexeeya xubinta taranka haweenka iyo deegaanka dibadda ayaa laga yaabaa inay horseeddo duulaanka bakteeriyada cudur-sidaha ee kala duwan, oo saameeya tayada gudaha iyo dibadda ee ukunta, iyo xitaa kordhinta heerka dhimashada iyo inay keento khasaare dhaqaale.Sanadihii la soo dhaafay, probiotics waxay faa'iido dhaqaale u keeneen xoolaha iyo wax soo saarka digaaga si ay u beddelaan antibiyootiga.Saamaynta maamulka siilka ee B. fragilis ee digaaga cloacal microbiota, transcriptome siilka iyo metabolome ayaa la baaray si loo qiimeeyo faa'iidada faa'iidada leh ee B. fragilis.Natiijooyinku waxay muujiyeen in daawaynta B. jilicsan ay saamaysay isku-dhafka microbial ee cloaca.Falanqaynta transcriptome waxay ogaatay in hiddo-wadaha difaaca ee CCN3, HAS2, iyo RICTOR la hagaajiyay, iyo hiddo-wadaha caabuqa EDNRB, TOX, iyo NKX2-3 ayaa hoos loo dhigay, iyo DEGs ayaa sidoo kale lagu kobciyay nidaamka caabuqa, dheef-shiid kiimikaadka gacanta, iyo dariiqyada jawaabta synaptik.Intaa waxaa dheer, dheef-shiid kiimikaad kala duwan ayaa inta badan la xidhiidha biosynthesis hoormoonka steroid, biosynthesis dufanka aan la daboolin, iyo dheef-shiid kiimikaadka aashitada arachidonic, iyo daraasaduhu waxay caddeeyeen ururada u dhexeeya dheef-shiid kiimikaad gaar ah iyo gen.Gebogebadii, daraasaddan ayaa bixinaysa aasaas aragtiyeed oo loogu talagalay adeegsiga B. Jilicsanaanta sida probiotic-ka suurtagalka ah ee wax soo saarka xoolaha iyo digaagga.
Foregene
Alaabooyinka La Xusay Suugaanta
RT Easy II (Master Premix oo loogu talagalay isku dhafka cDNA ee ugu horreeya ee qPCR)
Lambarka buugaagta: RT-01031
Tilmaam: 25 × 20 μL rxns
Cinwaanka maqaalka: Kala duwanaanshaha hidda-socodka Echinococcus granulosus sensu lato ee Shiinaha: Daraasadaha cudurrada faafa iyo dib u eegis nidaamsan
DOI: 10.1111/tbed.14469
Wakhtiga la sii daayo: 2022-2-9
Xiriirinta Qoraaga: Shaybaadhka Muhiimka ah ee Sichuan ee Horumarinta iyo Hal-abuurka Khayraadka Hiddaha ee Beeraha iyo Xoolaha
Soo koobid: Cystic echinococcosis (CE) waa cudur la dayacay oo kulaylaha zoonotic oo uu sababay Echinococcus granulosus oo weli ah dhibaato caafimaad oo guud oo caalami ah.Genotypes hore loo yaqaan ee Echinococcus granulosus oo aan ahayn G4 ayaa lagu aqoonsaday Shiinaha, gaar ahaan Qinghai-Tibet Plateau, kala duwanaanshahooda hidde-sidaha waa mid gaar u ah gobolkan adduunka.Marka loo eego dib-u-eegis nidaamsan, halabuurka hiddaha E. granulosa ee dalkaygu waa sida soo socota: E. granulosa (G1, G3), 98.3%;Echinococcus intermedius (G5), 0.1%;Echinococcus intermedius (G6, G7), 1.4%;iyo Canada Echinococcus (G8, G10), 0.2%.Gaar ahaan, heerka caabuqa G1 wuxuu ahaa 97.7% waxaana lagu asteeyay tiro badan oo martigeliyaha ah iyo qaybinta juqraafiga.Natiijooyinka cudurrada faafa waxay muujiyeen halbeegga hidde-sidaha E. coli oo xasiloon oo wanaagsan oo idaha iyo yaanka ah oo ka kala yimid saddex gobol oo CE ah oo aad u sarreeya (Xinjiang, Sichuan, iyo Qinghai).Idaha (287/406, 70.7%) ayaa lahaan jiray qayb sare oo fiix bacrin ah marka loo eego yak (28/184, 15.2%).29kii sano ee la soo dhaafay, waxaa Shiinaha ka dhacay 51 Echinococcus granulosus cox1 haplotypes.Haplotype-ka awoowayaasha (Hap_2) ayaa weli ah haplotype-ka ugu caansan, 12 haplotypes oo caadi ah ayaa la arkay, iyo 9 haplotypes oo dhowaan la soo sheegay ayaa la aqoonsaday intii lagu jiray sahanka.Natiijooyinka waxay soo jeedinayaan in tallaalka qasabka ah ee idaha iyo ololaha tijaabada tallaalka EG95 ee yaks ay si dhow ula socdaan heerka genotype ee hadda.
Foregene
Alaabooyinka La Xusay Suugaanta
La xidhiidh:
Maggie |Horumarinta Ganacsiga
Foregene Co., Ltd
M: +86-15281067355
URL: www.foreivd.com
Waqtiga boostada: Apr-08-2022
